TRACC PhD projects
Edinburgh and Glasgow host multiple research groups that are active in a broad spectrum of biomedical disciplines covering the full bench-to-bedside and bedsite-to-bench ranges. Our basic, translational and clinical studies are often performed in a collaborative and cross-disciplinary way. Consequently, the TRACC Programme offers a multitude of project opportunities – many of them involving teams from both cities. Although available projects will vary from year to year and will be tailored to fit interests of the TRACC Programme Fellows some representative example projects are listed in the table below.
Project Title |
Supervisor and Location |
|
|
Role of mitochondrial reprogramming in PPARG driven prostate cancer |
Imran Ahmad: CRUK Scotland Institute | |
| Tom MacVicar: CRUK Scotland Institute | ||
|
Development of novel pre-clinical models for paediatric sarcomas |
Nezha Benabdallah: Institute of Genetics and Cancer, University of Edinburgh | |
| Hannah Long: Institute of Genetics and Cancer, University of Edinburgh | ||
|
Microbial drivers of oronasal mucosal melanoma: spatial mapping, mechanistic insights, and clinical relevance |
Kelly Blacklock: Institute of Genetics and Cancer, University of Edinburgh | |
| Liz Patton: Institute of Genetics and Cancer, University of Edinburgh | ||
| Mark Stares: Institute of Genetics and Cancer, University of Edinburgh | ||
| Crispin Miller: CRUK Scotland Institute | ||
|
Therapeutic targeting of glioblastoma invasion |
Joanna Birch: School of Cancer Sciences, University of Glasgow | |
| Ross Cagan: School of Cancer Sciences, University of Glasgow | ||
| Neil Carragher: Institute of Genetics and Cancer, University of Edinburgh | ||
|
Investigating the clinical impact of radiation induced metastasis in Pancreatic Adenocarcinoma |
Joanna Birch: School of Cancer Sciences, University of Glasgow | |
| Derek Grose: School of Cancer Sciences, University of Glasgow | ||
| Jen Morton: CRUK Scotland Institute | ||
|
Get to know your neighbours – recording the conversations between cancer cells and their niche in tumour initiation |
Luke Boulter: Institute of Genetics and Cancer, University of Edinburgh | |
| Sally Lowell: Institute of Regeneration and Repair, University of Edinburgh | ||
| Tim Kendall: Institute of Regeneration and Repair, University of Edinburgh | ||
|
Pharmacological targeting of myeloid cells in glioblastoma to improve tumour control |
Paul Brennan: Centre for Clinical Brain Sciences, University of Edinburgh | |
| Neil Carragher: Institute of Genetics and Cancer, University of Edinburgh | ||
|
Therapeutic interventions to attenuate metastasis in colorectal cancer |
David Bryant: CRUK Scotland Institute | |
| Owen Sansom: CRUK Scotland Institute | ||
|
Understanding the impact of mutational heterogeneity in the early detection of pancreatic cancer
|
Marta Canel: Institute of Genetics and Cancer, University of Edinburgh | |
| Alan Institute of Genetics and Cancer, University of Edinburgh | ||
| Jen Morton, CRUK Scotland Institute | ||
|
Combining disease relevant 3D patient-derived glioblastoma/human brain organoid models with high content imaging for therapeutic development. |
Neil Carragher, Muhammad Furqan: Institute of Genetics and Cancer, University of Edinburgh | |
| Joanna Birch: School of Cancer Sciences, University of Glasgow | ||
|
The role of γδ T cells in the hepatic metastatic milieu in cancer |
Seth Coffelt: CRUK Scotland Institute | |
| Pavlina Spiliopoulou: School of Cancer Sciences, University of Glasgow | ||
|
Exploring the contribution of clonal haematopoiesis to multimorbidity in people living with cancer |
Mhairi Copland: School of Cancer Sciences, University of Glasgow | |
| Ninian Lang: School of Cardiovascular & Metabolic Health, University of Glasgow | ||
| Patricia Roxburgh: School of Cancer Sciences, University of Glasgow | ||
| Jennifer Lees: School of Cardiovascular & Metabolic Health, University of Glasgow | ||
| Gillian Horne: School of Cancer Sciences, University of Glasgow | ||
|
Targeting the RNA cap methyltransferases |
Vicky Cowling: CRUK Scotland Institute | |
| Immunology based: Ed Robert: CRUK Scotland Institute, Chris Halsey: School of Cancer Sciences, University of Glasgow | ||
| Glioma based: Joanna Birch: School of Cancer Sciences, University of Glasgow; Steve Pollard: Institute for Regenerative Medicine, University of Edinburgh | ||
| Intestinal based: Owen Sansom: CRUK Scotland Institute; Colin Steele: CRUK Scotland Institute | ||
|
Targeting metastasis through circadian rhythm interventions |
Zoi Diamantopoulou: CRUK Scotland Institute | |
|
Unbiased identification of degraders for cancer treatment |
Vincenzo D’Angiolella: Institute of Genetics and Cancer, University of Edinburgh | |
| Neil Carragher: Institute of Genetics and Cancer, University of Edinburgh | ||
| Charlie Gourley: Institute of Genetics and Cancer, University of Edinburgh | ||
|
Repurposing antipsychotic drugs for brain tumour treatment |
Noor Gammoh: Institute of Genetics and Cancer, University of Edinburgh | |
| Stephen Tait: CRUK Scotland Insitute | ||
|
Single-cell transcription: investigating the mechanistic origin and clinical impact of transcriptional plasticity in cancer |
Nick Gilbert: Institute of Genetics and Cancer, University of Edinburgh | |
| Davide Marenduzzo: School Physics and Astronomy, University of Edinburgh | ||
| Michelle Lockley: Barts Cancer Institute, QMUL, London | ||
|
Targeting autophagy to prevent childhood ALL relapse in the central nervous system |
Vignir Helgason: School of Cancer Sciences, University of Glasgow | |
| Chris Halsey: School of Cancer Sciences, University of Glasgow | ||
|
Enhancing tissue-specific detection of driver mutations by combining variant effect predictors with multiplexed assay data |
Joe Marsh: Institute of Genetics and Cancer, University of Edinburgh | |
| Colin Semple: Institute of Genetics and Cancer, University of Edinburgh | ||
|
Elucidating the role of protein translation elongation in CML through modulation of the eEF2K/eEF2 signalling axis |
Alison Michie, Heather Jorgensen, Mhairi Copland: School of Cancer Sciences, University of Glasgow | |
| Martin Bushell: CRUK Scotland Institute | ||
|
Dissecting the role of Activin signalling in Pancreatic Ductal Adenocarcinoma |
Jen Morton: CRUK Scotland Institute | |
| Gareth Inman: CRUK Scotland Insitute | ||
| Alan Serrels: Institute of Genetics and Cancer, University of Edinburgh | ||
|
Understanding the phenotypic transitions between normal and regenerative cells in inflammatory bowel disease and colorectal cancer |
Kevin Myant: Institute of Genetics and Cancer, University of Edinburgh | |
| Mark Arends: Institute of Genetics and Cancer, University of Edinburgh | ||
|
Extrachromosomal DNA (ecDNA) and DNA damage in glioblastoma |
Karin Purshouse: Institute of Genetics and Cancer, University of Edinburgh | |
| Wendy Bickmore: Institute of Genetics and Cancer, University of Edinburgh | ||
| Vincenzo D’Angiolella: Institute of Genetics and Cancer, University of Edinburgh | ||
|
Mechanistic exploration of genetic, environmental, and sex-specific risk factors to reduce colorectal cancer incidence and inequalities |
Vidya Rajasekaran: Institute of Genetics and Cancer, University of Edinburgh | |
| Susan Farrington: Institute of Genetics and Cancer, University of Edinburgh | ||
| Joanne Edwards: School of Cancer Sciences, University of Glasgow | ||
|
Identifying germline encoded melanoma antigens to develop cancer vaccination approaches |
Ed Roberts: CRUK Scotland Institute | |
| Pavlina Spiliopoulou: School of Cancer Sciences, University of Glasgow | ||
| Elizabeth Patton: Institute of Genetics and Cancer | ||
| Valeria Pavet: CRUK Scotland Institute | ||
| Jyoti Choudhury: Institute of Cancer Research, London | ||
|
Genomic complexity and survival in high grade serous ovarian cancer |
Colin Semple: Institute of Genetics and Cancer, University of Edinburgh | |
| Charlie Gourley: Institute of Genetics and Cancer, University of Edinburgh | ||
|
Exploring the impact of different KRAS mutations on the pancreatic cancer tumour microenvironment and mechanisms of immune evasion |
Alan Serrels: Institute of Genetics and Cancer, University of Edinburgh | |
| David Chang: School of Cancer Sciences, University of Glasgow | ||
| Fieke Froeling: School of Cancer Sciences, University of Glasgow | ||
| Marta Canel: Institute of Genetics and Cancer, University of Edinburgh | ||
|
Interrogating spatial relationships of neutrophil subtypes in primary and metastatic colorectal cancer |
Colin Steele: CRUK Scotland Institute | |
| Joanne Edwards, School of Cancer Sciences, University of Glasgow | ||
| Kevin Myant, Institute of Genetics and Cancer, University of Edinburgh | ||
|
Understand the role of epigenetic dysfunction in colorectal cancer |
Duncan Sproul, Institute of Genetics and Cancer, University of Edinburgh | |
| Kevin Myant, Institute of Genetics and Cancer, University of Edinburgh | ||
|
Incidence, care pathways and outcomes of colorectal cancer across demographic, geographic, and socioeconomic groups in Scotland |
Evropi Theodoratou, Caroline Jackson: Usher Institute, University of Edinburgh | |
| Malcolm Dunlop: Institute of Genetics and Cancer, University of Edinburgh | ||
|
Harnessing the microbiome to improve therapeutic efficiency in childhood acute lymphoblastic leukaemia |
Johan Vande Voorde: School of Cancer Sciences, University of Glasgow | |
| Chris Halsey: School of Cancer Sciences, University of Glasgow | ||
| Konstantinos Gerasimidis: School of Medicine, Dentistry &Nursing, University of Glasgow | ||
|
Metabolic rewiring of Cholangiocarcinoma |
Alex von Kriegsheim: Institute of Genetics and Cancer, University of Edinburgh | |
| Laura Randle: Institute of Systems, Molecular & Integrative Biology, University of Liverpool | ||
| Stephen Chapman: Institute of Systems, Molecular & Integrative Biology, University of Liverpool |